NBA 2K21 is a basketball simulation video game that was developed by Visual Concepts and published by 2K Sports, based on the National Basketball Association (NBA). It is the 22nd installment in the NBA 2K franchise and the successor to NBA 2K20. The game was released on September 4, 2020 for Nintendo Switch.

The game itself plays similarly to previous installments in the series. The player mainly plays NBA games with real-life or customized players and teams; games follow the rules and objectives of NBA games. Several game modes are present and many settings can be customized. Up to six expansion teams can be created and used in both MyLeague and MyGM Modes, with the possibility of a 36-team league, and any team can be relocated and rebranded. For the second time in series, all 12 WNBA teams are available to play as. There are 67 classic teams available, with the 2018–19 Toronto Raptors, 2016–17 Golden State Warriors, and 2015–16 Cleveland Cavaliers being among them.