ESPN NFL 2K5 is an American football video game developed by Visual Concepts for the PlayStation 2 console. Published by 2K Sports and the Sega Corporation, it is the sixth installment of the NFL 2K series and the last to use official NFL licensing until an unnamed sequel is released in 2021. Gameplay is presented as a live ESPN television broadcast and features the voices and digital likenesses of multiple ESPN on-air personalities.

The game features a franchise mode with a SportsCenter feature hosted by Chris Berman. He outlines the games of the current week with his co-host Trey Wingo who talks about the latest injuries and free agent deals and trades during the season. Mel Kiper Jr. hosts the draft portion of the segment while Suzy Kolber reports from the sidelines. There is also weekly preparation for the coming week which allows the player to make decisions on training and preparation. The player can also create his or her own team deciding the team logos (over 10 are available), team name, the team's city, the team's stadium look and build, jerseys and how good the team is. It also has a feature called first-person football, which gives the player the experience on the field looking from the eyes of the players. There is also the traditional create-a-player mode.