Sword of the Berserk: Guts' Rage is a hack and slash action video game for the Dreamcast. It is based on the popular Berserk manga by Kentarō Miura and the game is set between volume 22 and 23 of the manga; right after Guts and Puck depart for Elfhelm with Casca (chapter 182), but before Farnese, Serpico, and Isidro catch up with them (chapter 190).

After saving a traveling performer named Rita from bandits while on their way to Elfhelm, Guts, Casca, and Puck come to a small castle town to rest. Upon arriving, they learn of a disease that transforms its victims into "Mandragorans", making them go berserk and kill people, even their loved ones, without thinking. The ruler of the castle, Baron Balzac, learns of Guts killing a Mandragoran and brings him to the dungeon where people infected with the disease are kept. Balzac brings Guts to his laboratory while explaining that he is searching for a supposed cure. Guts learns from Balzac that the disease comes from an unusual plant, the Mandragora that grew into a tree located in a nearby village on the borders of his domain. After meeting a group of rebels that abducted Casca and learning the baron is a tyrant to their people, Guts decides to carry out Balzac's request for the Great Tree's heart since the baron's findings might provide a cure for Casca's madness. But while Guts is joined by Rita and a group of rebels, Balzac's men raid the rebels' hideout and capture Casca.