18 Wheeler: American Pro Trucker is an arcade game developed by Sega AM2 and distributed by Sega. The game was released in arcades in 2000 and ported to the Dreamcast in 2001.

The main purpose of the game is to make it to the finish line with the truck's cargo. Players are given a set amount of time, but can ram into special vans that will add three seconds to the timer. There are several characters to choose from, each with a unique truck and attributes.

The game starts out in New York City, New York and players travel across the United States of America, ending in San Francisco, California. After Stage 1, the game gives the player a choice of trailer. One trailer is harder to haul, but provides a bigger payoff while the other choice is easier to haul but provides a smaller payoff. Money is deducted from the total when the trailer is hit. Players can sound the truck's horn to make other cars on the road yield and slipstream behind large vehicles to gain a momentary speed boost.

In addition to the time limit, players also compete with the "Lizard Tail", a rival trucker. Crossing the finish line before the Lizard Tail yields additional money. In between levels, players can park the truck in a minigame to earn more cash and upgrades for their truck, such as an improved horn.