No More Heroes 2: Desperate Struggle is an action-adventure hack and slash video game developed for the Wii video game system, the sequel to 2007's No More Heroes. Desperate Struggle was produced by Suda51, developed by Grasshopper Manufacture and published by Ubisoft, Rising Star Games, and Marvelous Entertainment, and was released in North America on January 26, 2010, in Australia on May 25, 2010, in Europe on May 28, 2010, and in Japan on October 21, 2010.

The combat is similar to that of No More Heroes, with mechanics such as wrestling moves and deathblows returning. There are four beam katanas, which Travis can freely switch between in the middle of battle, each with different properties. For example, the Peony is a large and heavy sword with a wide range, and the Rose Nasty consists of two beam katanas which Travis dual-wields. There are two sections in which Shinobu and Henry are playable, both of whom have different capabilities from Travis. Shinobu can jump, and her section contains some platforming elements, while Henry has the ability of making a quick dash in all directions by using the B button on the Wii-remote.