Spider-Man and Venom: Maximum Carnage is a side-scrolling beat 'em up game for the Super Nintendo Entertainment System and Mega Drive/Genesis, developed by Software Creations and published by Acclaim Entertainment and its subsidiary LJN in 1994. The game, based on the comic book story arc of the same name, features numerous heroes, including Spider-Man, Venom, and their allies from the Marvel Comics fictional universe like Captain America, Black Cat, Iron Fist, Cloak and Dagger, Deathlok, Morbius and Firestar, all teaming up to battle an onslaught of villains led by Carnage, including Shriek, Doppelganger, Demogoblin and Carrion.

The first prints of the game for the Super NES and Genesis were sold in red-colored cartridges. Later prints came in standard-colored cartridges.

In this single-player side-scrolling beat 'em up (with a format similar to Double Dragon and Final Fight), the player controls Spider-Man and Venom through various levels to stop the supervillain Carnage and his team, as well as hundreds of criminals they inspire in their wake, from taking over the city. The two 16-bit versions are virtually identical.

Other Marvel heroes can be summoned by collecting appropriate items hidden within certain levels. The locations of the power-ups necessary to summon aid are set. Depending on which character summoned them, the summoned heroes may help out in different ways, usually being more effective for whichever character (Spider-Man or Venom) they favor.