Joe & Mac 2: Lost in the Tropics is a Super Nintendo Entertainment System video game and a sequel to Joe & Mac. It is the follow-up to Congo's Caper, the second game in the series.

A caveman named Gork has stolen the crown belonging to the Chief of Kali Village, and it's up to the player to retrieve it by using the seven rainbow stones that he will receive in the story.

The object of the game is to defeat Neanderthals with two caveman ninja heroes along with dinosaurs and huge level bosses. Each player controls either Joe or Mac with limited lives and continues. Players can also choose to fall in love with a girlfriend in their Stone Age village; giving her flowers and meat as presents. Once the player gets married, he gets to father a child. Stone wheels are the official currency in the game and players can replay levels in order to get more stone wheels. An overhead free roam map offers a chance for players to select their level like they were playing a console role-playing game. The action-packed levels are in side view.

Boss enemies include Stegosaurus, Pteranodon, Triceratops, Elasmosaurus, and Tyrannosaurus. After defeating each boss, the player will earn one of the rainbow stones. During the game, friendly creatures such as Pteranodon, Styracosaurus and Plesiosaurus will give the player a ride.