Triple Play Baseball is a baseball sports game released for the PlayStation, PlayStation 2 and Microsoft Windows in 2001. It would be the last game in the Triple Play series released for the PlayStation and Microsoft Windows. However it was the first game in the series to be released on the PlayStation 2. The game features Oakland Athletics first baseman Jason Giambi on the cover.

Triple Play Baseball was the first and only game in the triple play baseball series not to feature a year on the title. The new game featured a robust "create a player" option and Big League Challenge Mode. The players can play a single player game, a full season, playoffs, or Home Run Derby. Team selection and transfers come under player control. On the PS1 version, Jim Hughson and Buck Martinez provide the commentary, while on PS2 version it is Sean McDonough.

Singer Vitamin C provided motion capture for the video game, which featured her cover of The Waitresses' song "I Know What Boys Like".