TimeSplitters 2 is a first-person shooter that requires players to kill enemies and complete objectives using a variety of weapons and tactics in different predefined scenarios. Armour and health bars on the sides of the screen lower when the player is shot, which can be increased by walking over body armor and medical kits.

The weapons of TimeSplitters 2 include handguns, rifles, submachine guns, shotguns, rocket launchers, a grenade launcher, various explosives, a crossbow, a flamethrower, a fire extinguisher and a brick. They are of many different time periods, from the historical to the futuristic. Some weapons have an alternate fire which activates a feature such as launching a grenade or detonating a remote mine. It is possible to dual wield some weapons.