Tetrisphere is a falling block puzzle video game for the Nintendo 64 (N64) console. Developed by Canadian company H2O Entertainment, a nearly complete version of the game was originally slated for release on the Atari Jaguar in early 1995. After Nintendo obtained its publishing rights, Tetrisphere was reworked for the N64 and released on the platform in North America on August 11, 1997.

Tetrisphere is a variant on Tetris in which various shapes are shifted across a wrapped three-dimensional grid resembling a sphere, and then destroyed. The objective of the game changes depending on the mode but generally consists of removing layers of shapes to reach the playing field's core.