Spider-Man is a 2000 action-adventure video game based on the Marvel Comics series The Amazing Spider-Man. Although it features the likenesses and same voice actors, it is not based on the animated television shows from the 1990s.

The game follows Spider-Man as he is framed by a doppelgänger, making him a wanted criminal, and attempts to clear his name, while foiling a symbiote invasion plot orchestrated by Doctor Octopus and Carnage. The game features villains from the comics as bosses, including Scorpion, Rhino, Venom, Mysterio, Carnage and Doctor Octopus, as well as a Carnage symbiote-possessed Doctor Octopus, who was created exclusively for the game.