Road Rash 64 is a racing video game developed by Pacific Coast Power and Light and published by THQ for the Nintendo 64. The game is the fifth of six entries in the Road Rash series of video games, the only entry to be published by THQ and the only to be released for the Nintendo 64 platform.

The game plays similarly to previous games developed in the Road Rash series, which involves the player racing their motorcycle against other motorcyclists. While racing, the player has the option of punching, or using weapons to attack other racers, to slow down their progress.[3] The ultimate goal is to place first in the race, and do damage to others, in order to gain more money to upgrade the player's motorcycle. Conversely, the worst scenario is to be "busted" by police officers, who intervene when situations get too hectic or racers damage them, which costs the player money. If the player was unable to afford the fine, that game is over. In a similar situation, it was also possible to lose without getting busted; should a player's damages become sufficiently acute the motorcycle would be sent to a mechanic who would charge for parts and labor in order to get back into the game. Being unable to afford the mechanic's bill had the same consequences as being busted and unable to pay.