Pokémon Puzzle League is a puzzle game for the Nintendo 64 console. It is based on Nintendo's Puzzle League puzzle games, with Pokémon likenesses. It was released in North America starting in 2000. It is one of several Pokémon games to be based on the Pokémon anime, and features Ash Ketchum and other characters featured from the anime.

Pokémon Puzzle League features the same gameplay as in Panel de Pon. The objective is to clear blocks from the playfield by arranging them in horizontal or vertical lines of three or more blocks. A continuous stream of new blocks pushes up from the bottom of the playfield, causing the entire playfield to rise continuously. If the blocks reach the top of the playfield, the player loses. The player can temporarily stop the progression of blocks by scoring combos and chains, and in two-player battles, these actions also cause garbage blocks to stack on top of the opponent's playfield.

Unlike its predecessors, Pokémon Puzzle League features a 3D mode in addition to the traditional 2D mode. In this mode, gameplay takes place on a cylinder with an effective width of 18 blocks, compared to the six-block width of the flat 2D field. It also features the original block design from Panel de Pon and Tetris Attack, as well as a Pokémon-oriented design.

In two-player games, players can select one of fifteen Pokémon trainers to play as. Unlike most Pokémon games, trainer and Pokémon selection are purely cosmetic and do not affect gameplay whatsoever.