Ms. Pac-Man Maze Madness is a 2000 maze chase video game developed and published by Namco for the PlayStation. It was later released for the Nintendo 64.

Professor Pac learns that the evil forces have taken control of the Enchanted Castle, using black magic. The princess has vanished, and a witch named Mesmerelda is planning on stealing all four Gems of Virtue (Generosity, Truth, Wisdom, and Courage) to control the "four wonders" (areas of Pac-Land). These four areas each have enemies in them, and are blocked by mysterious force fields. Professor Pac creates a device called the Pactrometer, which allows Ms. Pac-Man to go to these areas to recover the gems before Mesmerelda can get them first. However, as the Professor is telling Ms. Pac-Man this, he gets sucked into a mirror by the witch, leaving Ms. Pac-Man with the Pactrometer. As she journeys through the areas, she is helped by video messages that the Professor placed in the Pactrometer, and by holograms of Professor Pac.

As Ms. Pac-Man gathers the last of the gems, they are stolen by Mesmerelda. A battle ensues and the witch is defeated and runs away, leaving behind a key. Without the key, Mesmerelda is unable to get into the castle to reach her crystal ball, and thus cannot use the gems.

Ms. Pac-Man returns to fight for the gems, and this time wins, regaining the gems. With them and the Pactrometer, the witch's spell is broken, and Mesmerelda returns to her true form as the princess.