Chameleon Twist 2 is a video game developed by Japan System Supply and published by Sunsoft for the Nintendo 64 released in 1998. It is the sequel to Chameleon Twist.

The story of Chameleon Twist 2 takes place after the events in Chameleon Twist. Davy and his friends (Jack, Fred, and Linda) are playing in the forest, still carrying the backpack from his last adventure, when suddenly the rabbit (closely resembling Lewis Carroll's White Rabbit) from before falls down and knocks one of the chameleons into the sky. The chameleon transforms into an enhanced-looking humanoid chameleon and goes on a search for six carrots in six different worlds.

The game changed certain aspects of the original, such as the character designs and the switched colors of the main characters. New moves were added, such as a parachute that could be deployed to make a slow descent and that could be used in conjunction with the tongue. Moreover, vertical pole swings were added, rather than having only horizontal.

The player may talk to the rabbit whenever it is encountered. The rabbit would ask them if they wanted to go to a practice course, and they could either accept or decline. If they declined, the rabbit would fly away and the player would not be able to visit that bonus course anytime again in the game.

The worlds are much longer than those of the first. However, there is no longer a multiplayer mode.