Teenage Mutant Ninja Turtles: The Hyperstone Heist is a side-scrolling beat 'em up based on the comic book characters the Teenage Mutant Ninja Turtles for the Sega Genesis.

The gameplay of The Hyperstone Heist is heavily based on the second TMNT arcade game, Turtles in Time, which was ported to the Super NES during the same year. The controls are similar to Turtles in Time, but the ability to dash is now assigned to a specific button and the player can no longer throw enemies towards the screen.

The game shares nearly the same soundtrack and sound effects as Turtles in Time, but the music plays faster in The Hyperstone Heist. Though there are fewer than half the levels as Turtles in Time, each level is longer. Furthermore, The Hyperstone Heist has a more aggressive enemy AI and faster-moving gameplay.

There are a total of five stages ("New York City", "A Mysterious Ghost Ship", "Shredder's Hideout", "The Gauntlet", and "The Final Shell Shock"), which comprise a combination of new levels created specifically for this game and ones based on levels from the first arcade game and Turtles in Time. The bosses include Leatherhead, Rocksteady, Tatsu, Baxter Stockman, Krang and Super Shredder.