Mutant League Football is a video game that was released in 1993 for the Sega Genesis. The game was designed using the Madden '93 engine, and features a different take on football, where the games resemble a war as much as a sporting competition.

The game deviates from usual football simulations in several ways. Most notably it takes place in a post-apocalyptic world where radiation has caused the human race to mutate and the dead to rise from the grave. The game instruction manual states that the exact causes of the upheaval have been lost or corrupted, due to (among many things) the chaos of an alien invasion, spin control, a sloppy filing system set up by a temp, and what appears to be barbecue sauce.