Mazin Saga: Mutant Fighter is a cross-genre game that blends side-scrolling beat 'em up and fighting playstyles where players take control of Koji Kabuto wielding the Mazinger Z armor through six stages, each one set in a different location across the world, to fight against enemies and powerful 'Bio Beasts' led by God Kaiser Hell. At the title screen, the player has access to the options menu where the difficulty settings can be adjusted between two levels.