Mega Man: Dr. Wily's Revenge is an action-platform video game by Capcom for the Nintendo Game Boy. It is the first game in the handheld series of the Mega Man franchise. It was released in North America in December 1991. The game continues the adventures of the android hero Mega Man as he once again confronts the evil Dr. Wily, who has dispatched his revived "Robot Masters" and a new "Mega Man Killer" named Enker.

Mega Man: Dr. Wily's Revenge is an action-platformer that shares many similarities with its NES counterparts. The player, as Mega Man, is able to choose among four stages to complete in whatever order desired. Each stage contains various enemies to blast through and obstacles to overcome, such as leaping between disappearing blocks over deadly spikes and bottomless pits. Mega Man's primary weapon is an arm cannon that has unlimited ammunition. Destroyed enemies typically leave items that replenish Mega Man's health or extra lives. At the end of every stage is a boss battle with a robot master, and defeating it earns the player its special weapon. Each boss is weak to another's weapon, allowing the player to strategize the order in which they are beaten.